Dendreon Corporation (NASDAQ:DNDN) is up 38.55% in late day trading at $10.53. DNDN has traded 40.6 million shares so far today, eight times its daily average volume. DNDN shares jumped today on Provenge cancer vaccine sales. The company has a market cap of 1.54 billion.

Ancestry.com Inc. (NASDAQ:ACOM) is up 20.16% today at $27.48. ACOM has traded 2.7 million shares today, well above its daily average of 885 thousand shares a day. ACOM shares are up today after the company reported a 22% increase in subscibers in 2011 and forecasts strong sales for 2012. The company has a market cap of 1.22 billion.

Network Engines, Inc. (NASDAQ:NEI) is up 17.31% in afternoon trading at $1.22. NEI has traded 1 million shares so far today, well above its daily average of 152 thousand shares. NEI is up today after they raised their first quarter outlook. The company has a market cap of 51.98 million.

Zumiez, Inc. (NASDAQ:ZUMZ) is up 16.29% near the close at $30.63. ZUMZ has traded 2.5 million shares today, more than 5 times its daily average. Zumiez announced it saw a 10% increase in same store sales for the five weeks ending December 31. Zumiez also raised their earnings guidance to $0.58, up from $0.52 to $0.54. The company has a market cap of 959.36 million.

Oclaro, Inc. (NASDAQ:OCLR) is up 15.31% today at $3.39. OCLR has traded 2.2 million shares this afternoon, more than double its average volume. Oclaro shares jumped today after they announced fourth quarter revenue beat guidance. The company has a market cap of 171.40 million.

Dex One Corporation (NYSE:DEXO) is up 14.06% today at $2.19. DEXO is up on large volume with 3.3 million shares traded, more than twice its daily volume. DEXO has jumped more than $0.40 a share over the past days. The company has a market cap of 109.01 million.

Axcelis Technologies Inc. (NASDAQ:ACLS) is up 11.03% this afternoon at $1.51. ACLS has traded 1.7 million shares today, well above the 550 thousand shares it trades on average daily. The company has a market cap of 158.65 million.

Bank of America Corporation (NYSE:BAC) is up 8.52% in late day trading at $6.30. BAC is up on extremely heavy volume with 435 million shares traded, nearly double its average volume. BAC has rallied more than $1 since last Thursday. The company has a market cap of 63.86 billion.